How Can NAD Help Fight COVID?
NAD levels are critically important to your body's immune response. But many viruses, including COVID, knock down your NAD levels. With less NAD, your immune system has a harder time fighting back. Indeed, lower NAD levels correspond with worse COVID outcomes.
That's why replenishing NAD before and during a viral attack can support your immune system and allow it to fight back.
Studies of coronaviruses generally, including COVID-19 in particular, reveal an immune system drama. When a COVID infection is detected, the cell's innate immune system attaches a large piece of an NAD molecule to the virus in order to interfere with the virus's ability to reproduce.
The problem is that coronaviruses have a counterattack, which is an enzyme that removes the piece of NAD. That process of attachment and removal burns up the cell's NAD and impairs immune response:
Infected cells expend NAD+ in antiviral ADP-ribosylating activities while the virus attempts to reverse these modifications. Indeed, coronavirus infection strikingly depletes cellular NAD+ level
By the virtue of its high capacity to actively reverse antiviral ADP-ribosylation, this virus accentuated pre-existing states of NAD+ deficiency
It is speculated that SARS-CoV-2 depletes cellular NAD+ levels by overexpressing a set of PARPs, all of which compete for the same NAD+ pool....which ultimately reduces NAD+ levels