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The vitamin B3 analogue nicotinamide riboside has only very minor effects on reducing muscle damage in mdx mice


February 6, 2023

Stan, Tiberiu Loredan


Our data showed a trend for increase in NAD+-levels in blood; only in the D2-mdx NR-treated mice the NAD+-levels were slightly increased. These markers were elevated in mdx models compared to controls, but not affected by the NR treatment. Histological analysis of muscle tissues indicated a mild treatment effect in D2-mdx mice. Based on our results, testing NR treatment in clinical trials in DMD patients is not warranted.

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