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The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation

Frontiers in Nutrition

August 26, 2021

Vanuytsel, Tim


An increased intestinal permeability has been described in various gastrointestinal and non-gastrointestinal disorders...Celiac disease is one of the conditions with the best evidence for impaired barrier function playing a crucial role with zonulin as its proposed regulator. Increased permeability is clearly present in inflammatory bowel disease, but the question of whether this is a primary event or a consequence of inflammation remains unsolved. The gut-liver axis with a crucial role in impaired intestinal barrier function is increasingly recognized in chronic alcoholic and metabolic liver disease...

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