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Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE

Oxidative Medicine and Cellular Longevity

July 18, 2022

Ren, Chengda


The present study demonstrated that NMN treatment could ameliorate the cellular senescence and retinal inflammation caused by NaIO3 exposure. This protective effect was executed upon NAD+ supplementation, which enhanced mitochondrial function, reduced DNA damage, and suppressed the activation of AMPK and Akt/mTOR signalling. NMN treatment also maintained the hexagonal structure of RPE in vivo and reduced senescence-related retinal inflammation. Moreover, undisturbed Sirt1 activity was required for NMN to exert its antisenescent effects. Overall, our results provided novel insights into the pathogenesis of age-related macular degeneration (AMD) and a potential therapeutic strategy for AMD from the perspective of cellular and histological senescence.

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