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Need for NAD+: Focus on Striated Muscle Laminopathies

Cells

October 7, 2020

Cardoso, Deborah

Summary

Laminopathies are a heterogeneous group of rare diseases caused by genetic mutations in the LMNA gene, encoding A-type lamins. A-type lamins are nuclear envelope proteins which associate with B-type lamins to form the nuclear lamina, a meshwork underlying the inner nuclear envelope of differentiated cells...Here, we have summarized these findings and reviewed the current knowledge about NAD+ alteration in striated muscle laminopathies, providing potential therapeutic approaches...NAMPT is important for muscle function. A recent study showed that deleting NAMPT in mice leads to a decreased NAD+ muscle content and a significant alteration in muscle mass and endurance...

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