google-site-verification=iUxCUgpoCQNGCS2CQuHi1L8aGqyfkykwcZUHtbSwrts Epithelial NAD + Depletion Drives Mitochondrial Dysfunction and Contributes to Intestinal Inflammation
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Epithelial NAD + Depletion Drives Mitochondrial Dysfunction and Contributes to Intestinal Inflammation

Frontiers in Immunology

August 1, 2023

Novak, Elizabeth

Summary

We demonstrate a significant depletion in the NAD + levels within the intestinal epithelium of mice undergoing experimental colitis, as well as humans with ulcerative colitis...Treatment of mice undergoing experimental colitis with an NAD + precursor reduced the severity of colitis, restored mitochondrial function, and increased active PGC1α levels

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231700/abstract

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