google-site-verification=iUxCUgpoCQNGCS2CQuHi1L8aGqyfkykwcZUHtbSwrts Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation
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Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation

Journal of Clinical Investigation Insight

July 24, 2023

Sun, Jingyuan

Summary

A rare mutation that disorganizes keratin filaments, and causes skin blistering and liver injury, can be treated with parthenolide, which has the effect of upregulating SIRT2. Giving mice NMN had a protective effect similar effect to parthenolide.

https://insight.jci.org/articles/view/166314

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