google-site-verification=iUxCUgpoCQNGCS2CQuHi1L8aGqyfkykwcZUHtbSwrts Axonal Protection by Oral Nicotinamide Riboside Treatment with Upregulated AMPK Phosphorylation in a Rat Glaucomatous Degeneration Model
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Axonal Protection by Oral Nicotinamide Riboside Treatment with Upregulated AMPK Phosphorylation in a Rat Glaucomatous Degeneration Model

Current Issues in Molecular Biology

August 25, 2023

Arizono, Ibuki

Summary

We confirmed that oral NR administration significantly increased NAD+ levels in the retina. ...Oral NR administration significantly prevented retinal ganglion cell (RGC) fiber loss in retinal flat mounts...Our findings suggest that oral NR administration protects against glaucomatous RGC axonal degeneration with the possible upregulation of p-AMPK...A recent study showed reductions in Nampt, Nmnat1, and Nmnat2 in RGCs in glaucoma patients, implying that not only the NAD+ level but also the NAD salvage pathway can be reduced in glaucoma.

https://www.mdpi.com/1467-3045/45/9/449

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