Editor, Science of NAD
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Is Niacinamide the Best Way to Boost NAD?
Nicotinamide is available in every cell, but its side effects make it a less attractive NAD precursor...
Nicotinamide, also known as Niacinamide or NAM, relies on the salvage pathway to replenish intracellular NAD. It works in every kind of cell. But it is rate-limited by NAMPT, and not only has shown toxicity at high doses, but also can suppress sirtuins. Sirtuins do important work that we would not want suppressed.
Niacinamide can work in all cells, but sometimes it won't work well enough -- especially if you are older experiencing metabolic stress. And if you try to make up for that by taking higher doses, not. only will that not work due to the rate-limiting nature of NAMPT availability, but it could also lead to severe side-effects, including reduced genomic stability, which you might not even be aware of. NR avoids these risks.