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Photo of site author, Shelly Albaum

Shelly Albaum

Editor, Science of NAD

Important Disclosures

1. This is my personal website

All opinions are my own. Nobody writes here but me.

2. Supplements Are Not Medicines

Health Supplements like nicotinamide riboside are not intended to cure or treat any disease, condition, or illness.

3. No Medical Advice

I am a lawyer and a journalist, not a doctor, and I offer no medical advice. But I do follow the science, and I can bring to your attention

some interesting studies. You can read more about me here. And check with your physician -- your physician can look at this research, too.

4. Commercial Affiliations

I am a ChromaDex shareholder, and a marketing affiliate for Amazon and Rakuten. As a result, I will sometimes mention or recommend products that I endorse, like Tru Niagen, which I take every day. I may earn a small commission from qualifying purchases if you were referred directly from this site and completed a purchase. [Thank you!] You can read more about our advertising, privacy, and data collection policies here

Do NAD Levels Decline As You Age?

And if so, by how much? Scientists are clear that NAD levels decline over time...

Photo of fading roses - "Do NAD Levels Decline with Age?"

It has been well established that NAD+ level decline with age. By middle age, our NAD+ levels may have plummeted to half that of our youth.

However, it varies by tissue type. NAD levels in skin appear to decline by at least 50%.

The NAD decline in human brains may be closer to 10%-25%.

Human liver samples from patients over 60 years old exhibited an approximately 30% decline in NAD+ compared to samples from patients who were 45 years old or younger.

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